Microscopes, Molecules & Mechanical Hearts

To understand nanoparticle trafficking, we must map the cell's interior with high-definition precision. My work utilises a combination of light and Soft X-ray imaging to locate nanoparticles, followed by FIB-SEM to "slice" through the cell and reveal their exact 3D environment. These overlapping scales provide a complete picture of how nanoparticles move through the cell so that we can better design the next generation of targeted drug therapies to ensure life-saving medicines reach their intended destination.

As a biomedical engineer I'm working on a PhD project at Royal college of Surgeons Ireland, which involves creating a library of digitally reanimated mitral valves and left ventricles

My research studies interferon-gamma, a human immune system protein. I aim to improve its stability by attaching PEG and glycans, helping it stay active longer to become a more effective therapy.